Choosing from a range of erectile dysfunction medications available on the pharmaceutical market, males pay due attention to Super Avana which is an innovative drug with a complex effect. Since the medication contains Avanafil and Dapoxetine as active ingredients, it enhances not only an ability to get and maintain an erection, sufficient for a sexual intercourse, but also balances the ejaculation process. In this article we will take a look at Avanafil and its mechanism of action.
Avanafil – One of Main Components of Effective ED Drug
Since Avana Super contains two core ingredients, the effect is also complex. Avanafil, being one of its components, is responsible for treatment of erectile dysfunction (the inability to achieve and hold an erection), also known as impotence. Avanafil is an orally active substance, selective inhibitor of phosphodiesterase type 5, which apart tadalafil and sildenafil is a first-choice and widely popular treatment of ED of different severity and etiology. It is a quite new PDE-5 inhibitor recently approved by the FDA based in several trials which showed its benefit over placebo and introduced into the market both as a single component and in a combination with other ingredients, thus, forming effective erectile dysfunction drugs.
Mechanism of Action
Avanafil is produced as white crystalline powder which is moderately soluble in organic solvents and minimally – in water. It works affecting the penile tissues by increasing the cGMP (cyclic guanosine monophosphate) level. After the increase the smooth muscles in the penis relax, thus, increasing the flow of blood to the penis, which results in erection gaining. At the same time the medication also influences the work of blood vessels that take blood away from the penile area. It decreases the size of the blood vessels, allowing less blood to be removed from the penis. As a result, one gets a strong, stiff and durable erection ever possible. In the body Avanafil is subjected to biotransformation through human cytochrome P450 enzyme system, which is responsible for the compound’s metabolism. However, it is important to note that Avanafil is effective only in case there has been sexual stimulation.
There have been several trials to study the effectiveness and safety of this component for ED treatment in male patients. As a result, patients treated with Avanafil saw significant improvement in their conditions if compared with those who got placebo, though some adverse effects were noticed, among which were flushing, headache, back pain, nasal congestion, bronchitis and nasopharyngitis. The researchers made a conclusion that Avanafil is quite effective in treatment of mild to severe impotence and well-tolerated in most patients. The response to the treatment was reported in 15 minutes after its administration, and some male patients noted Avanafil effects 6 hours after the intake.